Osmotic drug delivery systems make a major part of the various NDDS available in the market. Oral osmotically controlled release systems have great advantage of being independent of pH, presence of food and physiological factor like GI motility and transient time. Osmotic pump was suited for drug with moderate solubility and not for those giving high solubility. To overcome this problem Oros-push pull osmotic system were made. But the problem with this system was the complexity in the manufacturing technology i.e., the use of laser technology for formation of delivery orifice. Similar problem was encountered in other osmotic systems such as monolithic osmotic tablet systems and sandwiched osmotic tablet systems. Asymmetric membrane capsular system has been successfully used for the osmotic delivery of poorly water-soluble drug. As the release rate of drug through the asymmetric capsules is directly proportional to solubility of the drug, it has become a big problem for drugs with high solubility to be formulated into this type of system. So that we select water insoluble drug for this purpose, Nifedipine as model drug and controlled release was achieved for an extended period of time. Effect of different formulation variables was studied based on 23 factorial designs; namely, level of osmogen, level polymer and level of pore former. Differential scanning calorimetry showed no incompatibility between the drug and the excipient used in the study. Flow property, Drug content, Weight variation and Dissolution studied were carried out. Result show drug release dependent on the osmotic pressure of the dissolution medium.
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